Luíz Ricardo Orsini Tosi

This study shows that HUS1 and RAD9 subunits of the 9-1-1 checkpoint clamp have opposing roles in shaping genome plasticity in Leishmania major through distinct replication-stress responses and genome remodelling patterns.

This study shows that ATR modulates DNA replication timing in Leishmania major, promoting genome stability by preventing replication stress-induced chromosome instability.

This study shows TbAUK3 is essential for proper nuclear segregation and DNA stability in Trypanosoma brucei, with depletion causing segregation defects and increased DNA instability.

This study maps RPA1 and RAD9 in Leishmania to understand replication stress response, showing stress hotspots correlate with replication initiation and transcription termination.