Developmental convergence and divergence in human stem cell models of autism spectrum disorder
Aaron Gordon, Se‐Jin Yoon, Lucy K. Bicks, Jacqueline M. Martín, Greta Pintacuda, Stephanie Arteaga, Brie Wamsley, Qiuyu Guo, Lubayna S. Elahi, Ricardo E. Dolmetsch, Jonathan Adam Bernstein, Ruth M. O'Hara, Joachim Franz Hallmayer, Kasper Lage, Sergiu P. Pașca, Daniel H. Geschwind
The paper uses hiPS cell-derived cortical organoids to study how genetic mutations in ASD converge on shared transcriptional changes during development.
bioRxiv · Apr 1, 2024 · PreprintNeuroscience