Lucy K. Bicks

Nicotinic modulation of frontal circuits breaks the cycle of attentional performance failure

The paper identifies a cholinergic mechanism in frontal circuits that restores attentional performance after repeated errors in a mouse model.

A founder population reveals genetic variation with major effect on serious mental illness

The paper identifies a founder variant in ADAP1 associated with increased risk of schizophrenia and bipolar disorder in a Colombian genetic isolate.

The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders

The paper identifies five genomic factors explaining most genetic variance across 14 psychiatric disorders and finds shared and disorder-specific genetic signals with distinct biological functions.

Single-cell genomics and regulatory networks for 388 human brains

The paper processes single-nuclei multi-omics data from 388 human brains to identify regulatory elements and build cell-type networks, revealing changes in aging and neuropsychiatric disorders.

Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortex

The paper generates a molecular neuroanatomical map of the human prefrontal cortex using spatial transcriptomics and single nucleus RNA-sequencing, revealing novel spatial domains and cell-cell interactions linked to psychiatric disorders.

Molecular cascades and cell-type specific signatures in ASD revealed by single cell genomics

The paper uses single nuclear RNAseq and epigenetic profiling to identify molecular changes and cell-type specific signatures in ASD, linking them to genetic risk factors.

Developmental convergence and divergence in human stem cell models of autism spectrum disorder

The paper uses hiPS cell-derived cortical organoids to study how genetic mutations in ASD converge on shared transcriptional changes during development.

The Contributions of Rare Inherited and Polygenic Risk to ASD in Multiplex Families

This study identifies 74 ASD risk genes using whole genome sequencing of multiplex families and finds polygenic risk interacts with rare inherited variants.

NEURON-SPECIFIC CHROMOSOMAL MEGADOMAIN ORGANIZATION IS ADAPTIVE TO RECENT RETROTRANSPOSON EXPANSIONS

The paper shows that neuron-specific chromatin domains in mice are shaped by recent retrotransposon expansions and that disrupting a silencer leads to chromatin rewiring and neuroinflammation.