Brie Wamsley

Single-cell genomics and regulatory networks for 388 human brains

The paper processes single-nuclei multi-omics data from 388 human brains to identify regulatory elements and build cell-type networks, revealing changes in aging and neuropsychiatric disorders.

Molecular cascades and cell-type specific signatures in ASD revealed by single cell genomics

The paper uses single nuclear RNAseq and epigenetic profiling to identify molecular changes and cell-type specific signatures in ASD, linking them to genetic risk factors.

Developmental convergence and divergence in human stem cell models of autism spectrum disorder

The paper uses hiPS cell-derived cortical organoids to study how genetic mutations in ASD converge on shared transcriptional changes during development.

Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing

This study shows that Nova proteins, through activity-dependent alternative splicing, are essential for the maturation and connectivity of somatostatin interneurons.

Broad transcriptomic dysregulation across the cerebral cortex in ASD

The paper identifies widespread transcriptomic dysregulation across multiple cortical regions in ASD, showing regional variation and genetic enrichment in synaptic and protein folding genes.

cFIT: Integration and transfer learning of single cell transcriptomes, illustrated by fetal brain cell development

cFIT integrates and transfers single-cell transcriptomes across species and technologies, revealing transcriptional similarities in fetal brain development.

Rbfox1 mediates cell-type-specific splicing in cortical interneurons

This study identifies Rbfox1 as a cell-type-specific splicing regulator that shapes efferent connectivity in cortical interneurons through alternative splicing programs.