The paper investigates cellular mechanisms of brain overgrowth in autistic children with megalencephaly, finding elevated GPX4 and resistance to ferroptosis in neural progenitor cells.

1 citation

humanbulk RNA-seq

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NeurosciencebioRxivPreprintApr 1, 2024

Developmental convergence and divergence in human stem cell models of autism spectrum disorder

Aaron Gordon, Se‐Jin Yoon, Lucy K. Bicks…·Daniel H. Geschwind

The paper uses hiPS cell-derived cortical organoids to study how genetic mutations in ASD converge on shared transcriptional changes during development.

10 citations

humanbulk RNA-seq

𝕏 PostBluesky

Genetic & Genomic MedicineNature CommunicationsPeer-reviewedAug 30, 2022

Deconvoluting complex correlates of COVID19 severity with local ancestry inference and viral phylodynamics: Results of a multiomic pandemic tracking strategy

Victoria Nicole Parikh, Alexander G. Ioannidis, David Jimenez‐Morales…·Euan Angus Ashley

The paper integrates multi-omic data to identify genetic and microbiome factors associated with severe COVID-19, independent of ancestry and social factors.

11 citations

humanbulk RNA-seq

𝕏 PostBluesky

GeneticsbioRxivPreprintJul 22, 2018

Narcolepsy risk loci are enriched in immune cells and suggest autoimmune modulation of the T cell receptor repertoire

Hanna Maria Ollila, Eilon Sharon, Ling Lin…·Emmanuel Jean-Marie Mignot

This study identifies genetic risk loci for narcolepsy, showing enrichment in immune cells and suggesting autoimmune modulation via T cell receptor chains and influenza-A infection.

16 citations

humanGWAS summary statistics

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