Sergiu P. Pașca

Human organoid screen links transient translational modulation to progenitor progression in corticogenesis

The paper screens human cortical organoids with small molecules to identify translational modulators affecting progenitor progression in corticogenesis, finding Emetine promotes neuronal differentiation.

Human neuromodulatory assembloids to study serotonin signaling and disease

This study creates human neuromodulatory assembloids to investigate serotonin signaling and disease mechanisms, showing altered 5-HT dynamics in 22q11.2DS and rescue with SSRIs.

Human assembloid model of emergent neurotropic enteroviruses

The paper describes a human assembloid model to study enterovirus pathogenesis, showing that different EVs cause muscle contraction loss through distinct cellular mechanisms.

Human-specific tandem repeat in CACNA1C modulates responses to neuronal stimulation

The paper investigates a human-specific VNTR in CACNA1C and shows it modulates neuronal calcium responses and transcription programs.

Midline Assembloids Reveal Regulators of Human Axon Guidance

The paper develops a human midline assembloid model to study axon guidance and identifies GALNT2 as a human-specific regulator of commissural axon guidance.

Human assembloid model of the ascending neural sensory pathway

This study creates a human assembloid model of the ascending somatosensory pathway using pluripotent stem cells and demonstrates its functional connectivity and response to pain-related stimuli.

Generating human neural diversity with a multiplexed morphogen screen in organoids

This study uses a morphogen screen in human neural organoids to generate diverse neural cell types and uncover design principles of brain region specification.

An integrated transcriptomic cell atlas of human neural organoids

This paper integrates 36 single-cell transcriptomics datasets from human neural organoids into a unified atlas to assess cell type coverage and compare organoid protocols with primary brain tissue.

Assembloid model to study loop circuits of the human nervous system

The paper develops an assembloid model of the human cortico-striatal-thalamic-cortical circuit to study its function and disease-related disruptions.

Developmental convergence and divergence in human stem cell models of autism spectrum disorder

The paper uses hiPS cell-derived cortical organoids to study how genetic mutations in ASD converge on shared transcriptional changes during development.

Kirigami electronics for long-term electrophysiological recording of human neural organoids and assembloids

This paper introduces kirigami electronics for long-term, minimally-invasive electrophysiological recording of human neural organoids and assembloids in suspension.

CRISPR screens in 3D assembloids reveal disease genes associated with human interneuron development

The paper uses CRISPR screens in human forebrain assembloids to identify NDD genes involved in interneuron generation and migration, revealing novel roles for the ER in migration.

Human assembloids reveal the consequences of CACNA1G gene variants in the thalamocortical pathway

This study uses human assembloids to investigate how CACNA1G gene variants affect thalamocortical pathway function in neuropsychiatric disorders.

Selection of rAAV Vectors that Cross the Human Blood-Brain Barrier 1 and Target the Central Nervous System Using a Transwell Model

The paper identifies AAV capsids with improved blood-brain barrier penetration and CNS cell selectivity using a transwell model.

Stretchable mesh microelectronics for the biointegration and stimulation of neural organoids

This paper introduces a stretchable mesh electrode system for long-term electrical interfacing with human cortical organoids, demonstrating stable performance and successful integration with neural tissue.

Biocompatible polymers for scalable production of human neural organoids

This paper develops a scalable neural organoid platform using biocompatible polymers to prevent fusion, enabling drug and teratogen screening with over 2,400 cortical organoids.

Dissecting the molecular basis of human interneuron migrationin forebrain assembloids from Timothy syndrome

This study investigates interneuron migration defects in Timothy syndrome using human forebrain assembloids and identifies pharmacological targets to rescue migration abnormalities.

Landscape of human spinal cord cell type diversity at midgestation

The paper profiles midgestation human spinal cord cells at single-cell resolution, revealing early diversification of motor neurons and glial cell types.

Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution

The paper maps gene-regulatory dynamics in the developing human cerebral cortex using single-cell data, identifying key transcription factors and disrupted regulatory elements in ASD.