Franziska Lang

Mapping the immune landscape in small cell lung cancer unveils a distinct tumor-reactive CD8+ T cell molecular signature

This study identifies a CD8+ T cell molecular signature specific to small cell lung cancer, showing its prognostic value and potential for immunotherapy.

Computing tumor specificity of cancer antigen targets by k-mer indexing of healthy tissue transcriptomes

The paper introduces k4neo, a tool that computes tumor specificity of transcript variants by k-mer indexing of healthy tissue RNA-seq data, identifying tumor-specific antigens across multiple cancer cohorts.

Prediction of tumor-specific splicing from somatic mutations as a source of neoantigen candidates

This paper introduces splice2neo, a tool to identify tumor-specific splice junctions from somatic mutations, which can generate neoantigen candidates for immunotherapy.

Multiple instance learning to predict immune checkpoint blockade efficacy using neoantigen candidates

This study uses multiple instance learning to predict immune checkpoint blockade efficacy based on qualitative neoantigen profiles, showing better performance than quantitative approaches.