Author

Jennifer V. Gerbracht

University of CologneORCID 0000-0002-3377-4649Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Christoph DieterichiD· 2 shared Janine AltmülleriD· 2 shared Marcus KrügeriD· 2 shared Niels H. GehringiD· 2 shared Sebastian KallabisiD· 2 shared Thiago Britto‐BorgesiD· 2 shared Volker BoehmiD· 2 shared Ahmad Al AlwashiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMolecular Biology

Christoph DieterichORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Mapping the immune landscape in small cell lung cancer unveils a distinct tumor-reactive CD8+ T cell molecular signature

Krutika Khinvasara, Elif Diken, Jennifer V. Gerbracht, Enes Huduti, Joshua D’Rozario, Tana Omokoko, Sebastian Newrzela, Özlem Akilli‐Öztürk, Franziska Lang, Barbara Schrörs, Katja Hoepker, Eliana Stanganello, Maik Schork, Alessandra Gargano, Ahmad Al Alwash, , LAURA D. KOLB

This study identifies a CD8+ T cell molecular signature specific to small cell lung cancer, showing its prognostic value and potential for immunotherapy.

bioRxiv · Jul 3, 2026 · PreprintImmunology

Nonsense-mediated mRNA decay relies on "two-factor authentication" by SMG5-SMG7

Volker Boehm, Sabrina Kueckelmann, Jennifer V. Gerbracht, Sebastian Kallabis, Thiago Britto‐Borges, Janine Altmüller, Marcus Krüger, Christoph Dieterich, Niels H. Gehring

The paper reveals that SMG5-SMG7 and SMG6 work in a coordinated, hierarchical manner in NMD, with SMG5-SMG7 enabling SMG6 activity through UPF1 phosphorylation and heterodimer formation.

Nature Communications · Jun 25, 2021Peer-reviewedMolecular Biology

CASC3 promotes transcriptome-wide activation of nonsense-mediated decay by the exon junction complex

Jennifer V. Gerbracht, Volker Boehm, Thiago Britto‐Borges, Sebastian Kallabis, Janica L. Wiederstein, Simona Ciriello, Dominik Aschemeier, Marcus Krüger, Christian Karl Frese, Janine Altmüller, Christoph Dieterich, Niels H. Gehring

This study shows that CASC3 enhances NMD by linking the EJC to the NMD machinery, leading to increased degradation of NMD-targeted mRNAs.

Nucleic Acids Research · Jul 1, 2020Peer-reviewedMolecular Biology