Matthias M. Gaida

This paper develops a mouse model of idiopathic multicentric Castleman disease (iMCD) by targeting IL-6 to Foxp3+ Treg cells, showing that reducing soluble immunoglobulin production alleviates disease symptoms and improves survival.

The paper introduces k4neo, a tool that computes tumor specificity of transcript variants by k-mer indexing of healthy tissue RNA-seq data, identifying tumor-specific antigens across multiple cancer cohorts.

This study shows that lung-targeted cytokine RNA-lipoplexes enhance anti-tumor immunity by activating T and NK cells and reducing Tregs, with efficacy in murine models and human lung tumor cultures.

The paper identifies MPZL1 as a therapeutic target in 1q-amplified solid cancers by repurposing passenger amplifications as Trojan horses for targeted therapy delivery.

This study shows targeting CD44 on bone marrow-derived cells reduces pancreatic cancer metastasis by disrupting immunosuppressive niches in the liver.

This study shows that constitutive IκBζ expression in melanoma promotes tumor growth and immunotherapy resistance by suppressing cytokine production and immune cell recruitment.

The paper compares CCR8+ Treg cells in tumor and tumor-free tissues using chromatin accessibility and DNA methylation, finding high similarity suggesting tumor microenvironment activation of tissue Treg cells.