Small Structural Variations, Large Functional Consequences: Comparative Analysis Reveals Structural Control of Ubiquitylation Site Selection by BRCA1/BARD1
Sahar Heidari, Caitlin Lightle, Lauren Herrington, Tejas Shah, Fariha Hossain, Faruck Morcos, Susan T. Weintraub, Mikaela D. Stewart, Hedieh Torabifard
This study compares structural variations in BRCA1/BARD1 orthologs across species to show how a structural loop affects ubiquitylation site selection and chromatin regulation.
bioRxiv · Jul 1, 2026 · PreprintBiophysics