Tejas V. Shah

This study uses molecular dynamics simulations to show that oncogenic NSD2 mutations enhance catalytic efficiency by reorganizing conformational dynamics rather than destabilizing the enzyme.

This paper determines the cryo-EM structure of CbrA, revealing its SLC5-STAC domains and how CbrX interacts with the transporter, providing insights into histidine transport and signaling mechanisms.

This study compares structural variations in BRCA1/BARD1 orthologs across species to show how a structural loop affects ubiquitylation site selection and chromatin regulation.

This study uses molecular dynamics simulations to investigate how the BRCA1/BARD1-UbcH5c complex ubiquitinates H2A, highlighting the role of H3 in orienting the E2-Ub complex.