Hedieh Torabifard

This study uses molecular dynamics simulations to show that oncogenic NSD2 mutations enhance catalytic efficiency by reorganizing conformational dynamics rather than destabilizing the enzyme.

This study compares structural variations in BRCA1/BARD1 orthologs across species to show how a structural loop affects ubiquitylation site selection and chromatin regulation.

This study investigates how sodium and lithium regulate the fluoride exporter FEX, revealing structural and functional differences in their effects on channel activity and fluoride tolerance in yeast.

This study uses molecular dynamics simulations to reveal distinct transport mechanisms in Fluc's dual-pore structure and identifies a sodium ion's role as a dynamic cofactor in fluoride transport.

This study identifies the molecular mechanism of sodium-dependent fluoride export by FEX proteins using electrophysiology, cryo-EM, and simulations.

The paper designs artificial multidomain transmembrane transporters using a combined generative landscape and molecular dynamics approach, achieving native-like functionality.

This study uses molecular dynamics simulations to investigate how the BRCA1/BARD1-UbcH5c complex ubiquitinates H2A, highlighting the role of H3 in orienting the E2-Ub complex.