Emma R. Holden

This paper uses ICA to analyze TraDIS-Xpress data from E. coli, identifying functional modules of antimicrobial resistance genes across multiple stress conditions.

This study identifies genes critical for Pseudomonas aeruginosa biofilm survival under ciprofloxacin exposure, revealing key pathways and potential therapeutic targets.

The paper investigates how tazobactam affects multidrug resistance in E. coli and Klebsiella pneumoniae using transposon mutagenesis, finding it selects for efflux pumps and membrane permeability changes.

This study identifies the target pathway of a novel antimicrobial compound and discovers synergies with existing antibiotics using genome-wide screening in Gram-negative bacteria.

The paper identifies temporally essential genes for biofilm formation in E. coli using transposon mutagenesis and validates their roles at different stages of biofilm development.