Author

Thorsten Friedrich

University of FreiburgORCID 0000-0002-0813-7883Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

Adel BeghiahiD· 2 shared Jonas HentscheliD· 2 shared Patricia SauraiD· 2 shared Ville R. I. KailaiD· 2 shared Christoph von BallmoosiD· 1 shared Franziska HoeseriD· 1 shared H. Kim· 1 shared Jan Kägi· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiophysics

Adel BeghiahORCID

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3 papers

Recent·Most cited

Compartmentalized oxygen generation from hydrogen peroxide enables anaerobic oxidative phosphorylation and confers a fitness advantage

Stefan Urs Moning, Yannick Bärtschi, Lucia Heger, Jonas Hentschel, Jan Kägi, Thorsten Friedrich, Christoph von Ballmoos

This study shows that compartmentalized oxygen generation from hydrogen peroxide enables anaerobic oxidative phosphorylation in bacteria, providing a fitness advantage in oxygen-limited environments.

bioRxiv · Aug 3, 2026 · PreprintBiochemistry

A Carboxylate Switch Point Controls Long-Range Energy Transduction in Respiratory Complex I

Adel Beghiah, Patricia Saura, Terézia Kovaĺová, Franziska Hoeser, Thorsten Friedrich, Ville R. I. Kaila

This study identifies a carboxylate switch point in Complex I that mediates proton transfer and long-range PCET, showing its disruption leads to severe neurodegenerative disorders.

Nature Communications · Jul 1, 2026Peer-reviewedBiophysics

Redox-Triggered Coupling Network Mediates Long-Range Energy Trans-duction in Respiratory Complex I

Niklas Hoja, Jonas Hentschel, H. Kim, Thilo Seifermann, Adel Beghiah, Tim Schlosser, Patricia Saura, Thorsten Friedrich, Ville R. I. Kaila

The paper investigates the long-range energy transduction mechanism in Complex I using simulations and experiments, identifying key redox-triggered coupling sites.

bioRxiv · Apr 17, 2026 · PreprintBiophysics