Author

Patricia Saura

Stockholm UniversityORCID 0000-0003-2575-9913Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:cryo-EM· 4 Approach:statistical model· 3 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:plant (other)· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Ville R. I. KailaiD· 5 shared Adel BeghiahiD· 2 shared Thorsten FriedrichiD· 2 shared Ana P Gamiz-Hernandez· 1 shared Anja Schubert· 1 shared Anuj KumariD· 1 shared Asmit BhowmickiD· 1 shared Cecilia BlikstadiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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5 shared papersBiophysics

Ville R. I. KailaORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Electrostatic control of conformational dynamics drives proton translocation in respiratory Complex I

Jobst Liebau, Patricia Saura, Sofia Badolato, Ana P Gamiz-Hernandez, Ville R. I. Kaila

The paper investigates how electrostatic interactions control conformational changes and proton translocation in Complex I using a combination of experimental and computational methods.

bioRxiv · Nov 4, 2026 · PreprintBiophysics

A Carboxylate Switch Point Controls Long-Range Energy Transduction in Respiratory Complex I

Adel Beghiah, Patricia Saura, Terézia Kovaĺová, Franziska Hoeser, Thorsten Friedrich, Ville R. I. Kaila

This study identifies a carboxylate switch point in Complex I that mediates proton transfer and long-range PCET, showing its disruption leads to severe neurodegenerative disorders.

Nature Communications · Jul 1, 2026Peer-reviewedBiophysics

Redox-Triggered Coupling Network Mediates Long-Range Energy Trans-duction in Respiratory Complex I

Niklas Hoja, Jonas Hentschel, H. Kim, Thilo Seifermann, Adel Beghiah, Tim Schlosser, Patricia Saura, Thorsten Friedrich, Ville R. I. Kaila

The paper investigates the long-range energy transduction mechanism in Complex I using simulations and experiments, identifying key redox-triggered coupling sites.

bioRxiv · Apr 17, 2026 · PreprintBiophysics

Atomic resolution structure of spinach rubisco reveals protons and dynamics

Nicholas Croy, Guillaume Gaullier, Patricia Saura, Simonas Masiulis, Asmit Bhowmick, Jan F Kern, Oliver Raschdorf, Inger Andersson, Ville R. I. Kaila, Cecilia Blikstad, Johannes Messinger

The paper presents an atomic structure of spinach rubisco with a transition-state analogue, revealing protonation dynamics and structural flexibility, suggesting new strategies for enzyme redesign.

bioRxiv · Dec 23, 2025 · PreprintBiochemistry

Molecular principles of redox-coupled sodium pumping of the ancient Rnf machinery

Anuj Kumar, Jennifer Roth, Hyunho Kim, Patricia Saura, Stefan Bohn, Tristan Reif-Trauttmansdorff, Anja Schubert, Ville R. I. Kaila, Jan M. Schuller, Volker Müller

This study elucidates the molecular mechanism of redox-coupled sodium pumping in the Rnf complex using cryo-EM, biochemical assays, and simulations.

Nature Communications · Mar 7, 2025Peer-reviewedBiochemistry