Nikeisha J. Caruana

This study profiles subcellular proteomes in human skeletal muscle during acute exercise and endurance training, revealing compartment-specific protein remodeling and sex-conserved responses.

Nine vastus lateralis biopsies from before exercise to 48 h after one high-intensity interval session reveal 16,625 exercise-responsive genes; only four respond differently between males and females.

This study compares mitochondrial remodelling in humans after moderate-intensity continuous exercise and sprint-interval exercise, showing divergent adaptations in mitochondrial structure, function, and protein expression.

This study uses untargeted proteomics to rapidly prioritize genetic variants in mitochondrial and other rare diseases, achieving functional evidence for 83% of cases in a cohort.