David John Bishop

Normobaric hypoxia alters the transcriptional response of healthy human skeletal muscles to a single session of high-intensity interval exercise

This study examines how normobaric hypoxia affects gene expression in skeletal muscle after high-intensity interval exercise, finding more differentially expressed genes in hypoxia at 24 h post-exercise.

Subcellular proteomic profiling of human skeletal muscle reveals exercise-induced coordinated and compartment-specific protein remodeling

This study profiles subcellular proteomes in human skeletal muscle during acute exercise and endurance training, revealing compartment-specific protein remodeling and sex-conserved responses.

Exercise intensity modulates the human plasma secretome and interorgan communication

This study examines how different exercise intensities affect the human plasma secretome and interorgan communication through multi-cohort interventions and multi-organ gene expression analysis.

Exercise induces time-dependent but not sex-specific transcriptomic changes in healthy human skeletal muscle

Nine vastus lateralis biopsies from before exercise to 48 h after one high-intensity interval session reveal 16,625 exercise-responsive genes; only four respond differently between males and females.

Sprint interval exercise disrupts mitochondrial ultrastructure driving a unique mitochondrial stress response and remodelling in humans

This study compares mitochondrial remodelling in humans after moderate-intensity continuous exercise and sprint-interval exercise, showing divergent adaptations in mitochondrial structure, function, and protein expression.

Exercise and training regulation of autophagy markers in human and rodent skeletal muscle.

This study compares exercise-induced changes in autophagy markers in human and rodent skeletal muscle, finding differences in LC3B-II protein levels and autophagy flux responses.

Exercise twice-a-day potentiates markers of mitochondrial biogenesis in men

This study shows that exercising twice-a-day increases markers of mitochondrial biogenesis compared to once-daily exercise, suggesting the effect is due to two sessions rather than low glycogen.