Substrate induced activation in the conserved ribonuclease YicC
Kai Katsuya-Gaviria, Giulia Paris, Ben F. Luisi, Aleksei Lulla
The paper shows YicC, an RNA enzyme, preferentially cleaves specific sRNAs when they are in active, target-engaged structures, revealing a mechanism for substrate-induced conformational changes.
bioRxiv · May 21, 2026 · PreprintMolecular Biology