Aleksei Lulla

This study identifies cleavage sites and processing dynamics of astrovirus polyproteins, revealing conserved and divergent features between classical and non-classical strains.

The paper shows YicC, an RNA enzyme, preferentially cleaves specific sRNAs when they are in active, target-engaged structures, revealing a mechanism for substrate-induced conformational changes.

This study identifies di-arginine motifs in the N-terminal domain of astrovirus nsP1a that mediate ER retention and replication complex formation.