P. Brear

Targeting a Pleckstrin Homology Domain with a Lysine-Reactive Cova-lent Binder

The paper identifies a covalent binder targeting a lysine in the PIP3 binding site of BTK's PH domain, offering a novel approach to inhibit BTK beyond traditional ATP site targeting.

Two birds with one stone: a novel potential antibiotic blocking IsdB-mediated heme extraction by Staphylococcus aureus with serendipitous hemoglobin left-shifting activity

This paper identifies C35 as a dual-acting compound that inhibits Staphylococcus aureus growth by blocking heme acquisition and modulates hemoglobin oxygen affinity.

Transcriptome-scale analysis uncovers conserved residues in the hydrophobic core of the bacterial RNA chaperone Hfq required for small regulatory RNA stability

The paper identifies two conserved residues in Hfq critical for stabilizing small regulatory RNAs under nitrogen starvation.

Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture

This paper introduces a method to evolve protease activity and specificity using yeast display and alpha-2-macroglobulin-mediated covalent capture, demonstrating its application on six serine proteases.