Author

Michael R. Holbrook

National Institutes of HealthORCID 0000-0002-0824-2667Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:contrastive learning· 1 Approach:deep learning· 1

Frequent Co-Authors

Brett EatoniD· 2 shared Elena N. PostnikovaiD· 2 shared Michael J. MurphyiD· 2 shared Agnes Bugajska-SchretteriD· 1 shared Alexander Michael DohnaliD· 1 shared Alì MirazimiiD· 1 shared Alice Schwarzböck· 1 shared Anna Sanchez JimeneziD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersMicrobiology

Brett EatonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MicrobiologybioRxivPreprintSep 11, 2025

High-throughput virus quantification using cytopathic effect area analysis by deep learning

Michael J. Murphy, Steven Mazur, Elena N. Postnikova…·C. Paul Morris

This paper develops a deep learning-based method to quantify infectious viruses using cytopathic effect area analysis, improving throughput and reducing manual bias.

DOI 10.1101/2025.09.11.675495

imagingdeep learning

𝕏 PostBluesky

MicrobiologyJournal of VirologyPeer-reviewedOct 4, 2024

Antigenic cartography using hamster sera identifies SARS-CoV-2 JN.1 evasion seen in human XBB.1.5 booster sera

Wei Wang, Gitanjali L. Bhushan, Stephanie Paz…·Carol D. Weiss

The paper uses hamster sera to map antigenic differences among SARS-CoV-2 variants, showing JN.1 has significant antigenic divergence from XBB.1.5.

18 citationstop 3%

humanrat

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Molecular BiologyEMBO Molecular MedicinePeer-reviewedJul 4, 2022

Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants

Vanessa Monteil, Brett Eaton, Elena N. Postnikova…·Josef Martin Penninger

This paper shows that clinical-grade soluble ACE2 effectively inhibits multiple SARS-CoV-2 variants, including VOCs, in cell cultures and across independent labs.

59 citationstop 2%

humanexperimental assay

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