Author

Brett Eaton

National Institutes of HealthORCID 0000-0002-3060-2913Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Approach:contrastive learning· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Elena N. PostnikovaiD· 3 shared Matthew G. LackemeyeriD· 2 shared Michael J. MurphyiD· 2 shared Michael R. HolbrookiD· 2 shared Abel D. Ordonez· 1 shared Agnes Bugajska-SchretteriD· 1 shared Ahmad Jawad Sabir· 1 shared Alexander Michael DohnaliD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

Elena N. PostnikovaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Monkeypox Virus Clade IIb Isolate Exhibits Reduced Virulence Relative to Clade IIa Isolates in Multiple Murine Models

Stephanie V. Trefry, Santiago Vidal-Freire, Mayanka Awasthi, Abel D. Ordonez, Brett Eaton, Randy J. Hart, Christy N Raney, Amy L Cregger, Chase A Gonzales, Robert N Enamorado, Nelson A Martinez, Deborah S Gohegan, Matthew G. Lackemeyer, Tinoush Moulaei, N.E. Ziolkowska, , Farooq Nasar

This study compares the virulence of MPXV clade IIa and IIb isolates in multiple murine models, finding IIb is significantly less virulent with lower lethality.

Journal of Virology · Jul 15, 2026Peer-reviewedMicrobiology

High-throughput virus quantification using cytopathic effect area analysis by deep learning

Michael J. Murphy, Steven Mazur, Elena N. Postnikova, Brett Eaton, Gregory A. Kocher, Winston T. Chu, Matthew G. Lackemeyer, Syed Qasim Gilani, Jens H. Kuhn, Michael R. Holbrook, C. Paul Morris

This paper develops a deep learning-based method to quantify infectious viruses using cytopathic effect area analysis, improving throughput and reducing manual bias.

bioRxiv · Sep 11, 2025 · PreprintMicrobiology

Recombinant Pichinde reporter virus as a safe and suitable surrogate for high-throughput antiviral screening against highly pathogenic arenaviruses

Carolina Q. Sacramento, Ryan Bott, Qinfeng Huang, Brett Eaton, Elena N. Postnikova, Ahmad Jawad Sabir, Malaika D. Argade, Kiira M Ratia, Manu Anantpadma, Paul R. Carlier, Hinh Ly, Yuying Liang, Lijun Rong

This paper develops a high-throughput screening assay using a non-pathogenic arenavirus to identify antiviral compounds against highly pathogenic arenaviruses.

Antiviral Research · Feb 17, 2025Peer-reviewedMicrobiology

Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants

Vanessa Monteil, Brett Eaton, Elena N. Postnikova, Michael J. Murphy, Benedict Braunsfeld, Ian Crozier, Franz Kricek, Janine Niederhöfer, Alice Schwarzböck, Helene Breid, Stéphanie Devignot, Jonas Klingström, Charlotte Thålin, Max J. Kellner, Wanda Christ, , Josef Martin Penninger

This paper shows that clinical-grade soluble ACE2 effectively inhibits multiple SARS-CoV-2 variants, including VOCs, in cell cultures and across independent labs.

EMBO Molecular Medicine · Jul 4, 2022Peer-reviewedMolecular Biology