Author

Jeyaram Ravichandran Damodaran

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-0825-5572Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:variant calling· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Danwei HuangfuiD· 3 shared Dingyu LiuiD· 3 shared Hyunwoo ChoiD· 3 shared Renhe LuoiD· 3 shared Samuel J. KaplaniD· 3 shared Christina S. LeslieiD· 2 shared Dapeng YangiD· 2 shared Denis TorreiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersDevelopmental Biology

Danwei HuangfuORCID

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3 papers

Recent·Most cited

Developmental BiologyCell GenomicsPeer-reviewedMar 18, 2026

Discovery of Competent Chromatin Regions in Human Embryonic Stem Cells

Julián Pulecio, Zakieh Tayyebi, Dingyu Liu…·Danwei Huangfu

The paper identifies pre-established chromatin regions in human ESCs that enable rapid activation of lineage-specific genes during differentiation.

5 citations

Cancer BiologybioRxivPreprintMar 11, 2026

A Genetically Engineered Human Organoid Model Reveals Distinct Genetic and Epigenetic Barriers of Lineage Plasticity in Early PDAC Transformation

X Zhang, W. Douglas Wong, Hyunwoo Cho…·Danwei Huangfu

This paper develops a human organoid model of early PDAC that identifies genetic and epigenetic barriers to lineage plasticity, showing CDKN2A loss is essential with KRAS/TP53 mutations and TET1 suppression links ERK signaling to transcription factor silencing.

DOI 10.64898/2026.03.09.710586

Developmental BiologyNature CommunicationsPeer-reviewedOct 17, 2024

Parallel genome-scale CRISPR-Cas9 screens uncouple human pluripotent stem cell identity versus fitness

Bess P. Rosen, Qing V. Li, Hyunwoo Cho…·Danwei Huangfu

The paper uses CRISPR-Cas9 screens to identify genes affecting stem cell fitness versus pluripotency identity, finding distinct and overlapping roles for chromatin and metabolic regulators.

15 citations

humanCRISPR screen