Author

X Zhang

Memorial Sloan Kettering Cancer CenterORCID 0009-0004-9230-4593Unclaimed ORCID profile · follow to get notified of new preprints

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X Zhang5 papers · University of Iowa

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Adrien GrimontiD· 1 shared Aslihan YavasiD· 1 shared Christina S. LeslieiD· 1 shared Christine A. Iacobuzio–DonahueiD· 1 shared Danwei HuangfuiD· 1 shared Dapeng YangiD· 1 shared Denis TorreiD· 1 shared Dingyu LiuiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Adrien GrimontORCID

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1 paper

Recent·Most cited

A Genetically Engineered Human Organoid Model Reveals Distinct Genetic and Epigenetic Barriers of Lineage Plasticity in Early PDAC Transformation

X Zhang, W. Douglas Wong, Hyunwoo Cho, Dapeng Yang, Gary Dixon, Renhe Luo, Dingyu Liu, Denis Torre, Shigeaki Umeda, Federico Gonzãlez, Gökçe Aşkan, Aslihan Yavas, Jeyaram Ravichandran Damodaran, Robert W. Rickert, Rajya L. Kappagantula, , Danwei Huangfu

This paper develops a human organoid model of early PDAC that identifies genetic and epigenetic barriers to lineage plasticity, showing CDKN2A loss is essential with KRAS/TP53 mutations and TET1 suppression links ERK signaling to transcription factor silencing.

bioRxiv · Mar 11, 2026 · PreprintCancer Biology