Regulation of Renal Transporters by Pro-inflammatory Cytokines in Human Proximal Tubular Epithelial Cells: Identification of the Perpetrator and Mechanisms
Yik Pui Tsang, Kai Wang, Edward J. Kelly, Qingcheng Mao, Jashvant D. Unadkat
This study identifies IL-1β as the main cytokine downregulating renal transporters in PTECs, with distinct signaling pathways for different transporters.
ACS Pharmacology & Translational Science · Jun 23, 2026Peer-reviewedPharmacology & Toxicology