Edward J. Kelly

Proteomic profiling of drug and nutrient transporter expression by small intestinal region in neonates, pediatrics, and adults

This study quantifies transporter protein abundance in small intestinal regions across neonates, pediatrics, and adults using mass spectrometry, identifying region-specific and age-related expression patterns.

Voclosporin Preserves Mitochondrial Function Compared With Cyclosporine A in Perfused Human Proximal Tubule Microphysiological Systems

This study compares voclosporin and cyclosporine A in 3D kidney MPS, finding that voclosporin preserves mitochondrial function and reduces proteostatic stress compared to cyclosporine A.

Regulation of Renal Transporters by Pro-inflammatory Cytokines in Human Proximal Tubular Epithelial Cells: Identification of the Perpetrator and Mechanisms

This study identifies IL-1β as the main cytokine downregulating renal transporters in PTECs, with distinct signaling pathways for different transporters.

Differential retinoic acid responses across testicular development in vitro

The paper examines how retinoic acid responses differ during testicular development in vitro, showing dose-dependent Stra8 activation and media effects on spermatogonial markers.

Evaluation of toxicological mechanisms of ochratoxin-A in human primary proximal tubule epithelial cells

This study investigates OTA toxicity in human kidney cells, showing it causes mitochondrial dysfunction, oxidative stress, and reduced energy production, contributing to kidney disease.