Jashvant D. Unadkat

Proteomic profiling of drug and nutrient transporter expression by small intestinal region in neonates, pediatrics, and adults

This study quantifies transporter protein abundance in small intestinal regions across neonates, pediatrics, and adults using mass spectrometry, identifying region-specific and age-related expression patterns.

Cortisol Drives Pregnancy-Associated Induction of Hepatic OAT2, NTCP, and OCT1 in HepaRG cells Through GR-, HNF1α-, and HNF4α-Dependent Signaling

This study identifies cortisol as the main pregnancy-related hormone inducing hepatic transporters OAT2, NTCP, and OCT1 in HepaRG cells via GR, HNF4, and HNF1 signaling.

Prenatal cannabis exposure affects human fetal neurodevelopment: anintegrated multi-omics study

This study investigates the molecular effects of prenatal cannabis exposure on human fetal brains, finding significant disruptions in male second trimester brains linked to neurodevelopmental disorders.

Proteomic profiling of xenobiotic and nutrient transporters in human placenta of different gestational ages

This study profiles membrane-associated proteins in human placenta across pregnancy trimesters, identifying changes in transporter abundance linked to gestational age.

Regulation of Renal Transporters by Pro-inflammatory Cytokines in Human Proximal Tubular Epithelial Cells: Identification of the Perpetrator and Mechanisms

This study identifies IL-1β as the main cytokine downregulating renal transporters in PTECs, with distinct signaling pathways for different transporters.