Author

Yik Pui Tsang

University of WashingtonORCID 0009-0007-9541-3199Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Edward J. KellyiD· 2 shared Jashvant D. UnadkatiD· 2 shared Catherine K. YeungiD· 1 shared Eric W. HsuiD· 1 shared James W. MacDonaldiD· 1 shared Jonathan HimmelfarbiD· 1 shared Kai WangiD· 1 shared Kayenat S Aryeh· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPharmacology & Toxicology

Edward J. KellyORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Pharmacology & ToxicologyDrug Metabolism and DispositionPeer-reviewedAug 3, 2026

Cortisol Drives Pregnancy-Associated Induction of Hepatic OAT2, NTCP, and OCT1 in HepaRG cells Through GR-, HNF1α-, and HNF4α-Dependent Signaling

Sejal Sharma, Yik Pui Tsang, Jashvant D. Unadkat

This study identifies cortisol as the main pregnancy-related hormone inducing hepatic transporters OAT2, NTCP, and OCT1 in HepaRG cells via GR, HNF4, and HNF1 signaling.

DOI 10.1016/j.dmd.2026.100383

humanbulk RNA-seq

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Pharmacology & ToxicologybioRxivPreprintJul 11, 2026

Voclosporin Preserves Mitochondrial Function Compared With Cyclosporine A in Perfused Human Proximal Tubule Microphysiological Systems

Kayenat S Aryeh, Yik Pui Tsang, Eric W. Hsu…·Edward J. Kelly

This study compares voclosporin and cyclosporine A in 3D kidney MPS, finding that voclosporin preserves mitochondrial function and reduces proteostatic stress compared to cyclosporine A.

DOI 10.64898/2026.07.07.737071

humanproteomics

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Pharmacology & ToxicologyACS Pharmacology & Translational SciencePeer-reviewedJun 23, 2026

Regulation of Renal Transporters by Pro-inflammatory Cytokines in Human Proximal Tubular Epithelial Cells: Identification of the Perpetrator and Mechanisms

Yik Pui Tsang, Kai Wang, Edward J. Kelly…·Jashvant D. Unadkat

This study identifies IL-1β as the main cytokine downregulating renal transporters in PTECs, with distinct signaling pathways for different transporters.

2 citations

humanbulk RNA-seq

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