This study identifies two distinct cell proliferation populations during liver regeneration in mice with acute liver injury using single-cell RNA-seq.

Stem Cell Reports · May 8, 2025Peer-reviewedPathology

Wide scope analysis of bioactive lipids, including steroids, bile acids, and polyunsaturated fatty acid metabolites, in human plasma by LC/MS/MS

Kohta Nakatani, Yoshihiro Izumi, Hironobu Umakoshi, Maki Yokomoto‐Umakoshi, Tomoko Nakaji, Hiroki Kaneko, Hiroshi Nakao, Yoshihiro Ogawa, Kazutaka Ikeda, Takeshi Bamba

The paper develops an LC/MS/MS method to measure over 140 bioactive lipids in human plasma, revealing sex and circadian differences.

bioRxiv · Apr 13, 2023 · PreprintSystems Biology

Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle

Kiyoshi Yoshioka, Hiroshi Nagahisa, Fumihito Miura, Hiromitsu Araki, Yasutomi Kamei, Yasuo Kitajima, Daiki Seko, Jumpei Nogami, Yoshifumi Tsuchiya, Narihiro Okazaki, Akihiko Yonekura, Seigo Ohba, Yoshinori Sumita, Ko Chiba, Kosei Ito, , Yusuke Ono

This study identifies Hoxa10 as a mediator of positional memory in adult skeletal muscle stem cells, linking embryonic gene expression to region-specific regenerative capacity.

Science Advances · Jun 9, 2021Peer-reviewedDevelopmental Biology