Dennis Tin Chat Chan

Fine Tuning Genetic Circuits via Host Context and RBS Modulation

This study fine-tunes a genetic toggle switch by varying host contexts and ribosome binding sites to optimize performance metrics like signaling strength and inducer sensitivity.

Pangenomic Landscapes Shape Performances of a Synthetic Genetic Circuit Across Stutzerimonas Species

The paper investigates how genome structure and function influence the performance of a synthetic genetic circuit across six Stutzerimonas species, revealing that core genome expression drives observed differences.

Revealing the chassis-effect on a broad-host-range genetic switch and its concordance with interspecies bacterial physiologies

This study investigates the chassis-effect in genetic switches across bacterial hosts, finding that physiological similarity correlates with toggle switch performance.