Peter Mullen

A phosphoramidate modification of FUDR, NUC-3373, causes DNA damage and DAMPs release from colorectal cancer cells, potentiating lymphocyte-induced cell death

NUC-3373, a phosphoramidate-modified FUDR, induces DNA damage and DAMPs release in CRC cells, enhancing lymphocyte-mediated cell death and synergizing with PD-1 inhibitors.

Long-read Spatial Transcriptomic Profiling of Patient-derived ccRCC Tumoroids Reveals Heterogeneity in Isoform and Gene Expression

The paper uses long-read spatial transcriptomics on ccRCC tumoroids to reveal gene and isoform expression heterogeneity, identifying distinct functional tumor clusters and isoform-specific patterns.