BACH2 dosage establishes the hierarchy of stemness and finetunes antitumor immunity in CAR T cells
Taidou Hu, Ziang Zhu, Luo Ying, Safuwra Wizzard, Jonathan Hoar, Sejal S. Shinde, Kiddist D. Yihunie, Chen Yao, Tuoqi Wu
This study shows that BACH2 dosage regulates stemness hierarchy and antitumor immunity in CAR T cells, with tunable control improving therapeutic outcomes.
Nature Immunology · Jan 16, 2026Peer-reviewedCancer Biology