MeiLu McDermott

Cell cycling throttles epithelial--mesenchymal transition

This study shows that G1 phase cells exhibit stronger EMT gene expression and RNA velocity than cycling cells, suggesting cell cycle phase influences EMT and should not be regressed out.

A Mecom—Cdk6 toggle switch governs hematopoietic stem-to-multipotent fate transitions via distinct multistable landscapes

The paper models the Mecom-Cdk6 regulatory network to show how IGF signaling and self-activation shape stem cell fate transitions through multistable landscapes.

Modeling the dynamics of EMT reveals genes associated with pan-cancer intermediate states and plasticity

The paper models EMT dynamics across cancers to identify genes associated with intermediate states and plasticity, finding SFN and NRG1 as key markers.

Data-driven model discovery and model selection for noisy biological systems

This paper introduces a framework for model discovery and selection in noisy biological systems using hybrid dynamical systems and neural networks, showing improved performance over existing methods.

APIR: Aggregating Universal Proteomics Database Search Algorithms for Peptide Identification with FDR Control

APIR aggregates database search algorithms for proteomics to increase peptide identification while controlling FDR, outperforming individual methods on standard and real data.

Clipper: p-value-free FDR control on high-throughput data from two conditions

Clipper provides a p-value-free FDR control method for high-throughput data from two conditions, outperforming existing approaches without relying on p-values or distributional assumptions.