Evanthia T. Roussos Torres

Computational modeling of breast cancer metastases predicts response to dual checkpoint inhibition and reveals spatially-informed treatments

The paper develops an agent-based model of breast cancer metastases to predict responses to dual checkpoint inhibition and identifies spatially-informed treatment strategies.

A class act: HDAC1-Malat1 regulates MDSC apoptosis and cell cycling to decrease suppression of T cells

The paper shows HDAC1 inhibition in MDSCs increases Malat1, decreases pSTAT3, induces apoptosis and cell cycle arrest, and reduces T cell suppression.

Beyond RECIST: mathematical modeling and Bayesian inference reveal the importance of immune suppressive parameters in metastatic breast cancer

The paper develops mathematical models and Bayesian inference methods to analyze tumor-immune dynamics in metastatic breast cancer, revealing immune suppressive parameters as key predictors of response to immunotherapy.

Cancer systems immunology reveals myeloid - T cell interactions and B cell activation mediate response to checkpoint inhibition in metastatic breast cancer

The paper investigates how myeloid-T cell interactions and B cell activation influence response to checkpoint inhibition in metastatic breast cancer using multi-omics and computational methods.

Inference of marker genes of subtle cell state changes via iterative logistic regression

This paper introduces iterative logistic regression (iLR) to identify small sets of marker genes for subtle cell state changes, showing high accuracy in distinguishing cell subtypes and predicting therapeutic effects.

Modeling the dynamics of EMT reveals genes associated with pan-cancer intermediate states and plasticity

The paper models EMT dynamics across cancers to identify genes associated with intermediate states and plasticity, finding SFN and NRG1 as key markers.

Intratumoral CXCL12 Gradients Contextualize Tumor Cell Invasion, Migration and Immune Suppression in Breast Cancer

This study shows CXCL12 gradients around TMEM doorways promote tumor cell invasion and create immunosuppressive niches by affecting CD8+ T cell function and distribution.

Targeting MDSC-HTR2B to Improve Immune Checkpoint Inhibitors in Breast to Brain Metastasis

The paper identifies HTR2B on MDSCs as a target to enhance immune checkpoint inhibitors in breast-to-brain metastasis using clozapine and anti-PD-1 therapy.

Cell of origin alters myeloid-mediated immunosuppression in lung adenocarcinoma

This study shows that the cell of origin in lung adenocarcinoma affects the immunosuppressive state of the tumor microenvironment, with AT1-derived tumors showing an anti-tumor immune profile and AT2-derived tumors showing immunosuppressive features.

Targeting circadian transcriptional programs in triple negative breast cancer through a cis-regulatory mechanism

This paper identifies a cis-regulatory mechanism in triple-negative breast cancer where targeting circadian transcription factors with small molecules represses a circadian transcriptional program, offering a new therapeutic strategy.

Myeloid-derived suppressor cell dynamics control outcomes in the metastatic niche

This study develops a mathematical model to analyze MDSC dynamics in metastatic niches, showing that MDSC delays and suppression capabilities significantly impact metastasis outcomes.

Expression variation analysis for tumor heterogeneity in single-cell RNA-sequencing data

This paper introduces EVAsc, a method to analyze expression variation in scRNA-seq data to quantify tumor heterogeneity across cell types, subtypes, and patients.