This study uses a coarse-grained model to show DNA length and flexibility influence protein-DNA condensate structure and protein dynamics, revealing multiphasic organization and differential diffusion modes.

The Journal of Physical Chemistry B · Sep 15, 2025Peer-reviewedBiophysics

rtPA Directly Protects Neurons After Intracerebral Hemorrhage through PI3K/AKT/mTOR Pathway

Jie Jing, Shiling Chen, Xuan Wu, Jingfei Yang, Xia Liu, Jiahui Wang, Jingyi Wang, Yunjie Li, Ping Zhang, Zhouping Tang

The paper investigates the neuroprotective effects of rtPA after ICH, showing it reduces apoptosis and autophagy via the PI3K/AKT/mTOR pathway.

bioRxiv · Feb 13, 2023 · PreprintNeuroscience

ChIA-PIPE: A fully automated pipeline for ChIA-PET data analysis and visualization

Byoungkoo Lee, Jiahui Wang, Liuyang Cai, Minji Kim, Sandeep Namburi, Harianto Tjong, Yuliang Feng, Ping Wang, Zhonghui Tang, Ahmed Abbas, Chia‐Lin Wei, Yijun Ruan, Sheng Li

ChIA-PIPE is a fully automated pipeline for analyzing and visualizing ChIA-PET data, including quality assessment and visualization tools.

Science Advances · Jul 10, 2020Peer-reviewedBioinformatics

BTB-TAZ domain protein MdBT2 modulates malate accumulation by targeting a bHLH transcription factor for degradation in response to nitrate

Quan‐Yan Zhang, Kai‐Di Gu, Lailiang Cheng, Jiahui Wang, Jian‐Qiang Yu, Xiao‐Fei Wang, Chun‐Xiang You, Da‐Gang Hu, Yu‐Jin Hao

The paper identifies MdBT2 as a regulator of malate accumulation in apple by ubiquitinating and degrading MdCIbHLH1 in response to nitrate.

bioRxiv · Oct 21, 2019 · PreprintMolecular Biology