Endosome maturation is orchestrated by inside-out proton signaling through a Na+/H+ exchanger and pH-dependent Rab GTPase cycling
Youjin Lee, Qing Ouyang, Li Ma…·Eric M. Morrow
The paper shows that endosome maturation is regulated by proton signaling through NHE6 and pH-dependent Rab7 cycling, with implications for neurodegeneration.