One-Pot NADH-Mediated Physiological Redox-Controlled Synthesis of Papain-Stabilized Copper Nanoclusters with Preserved Bioactivity for Efficient Drug Delivery
Aman Singh, Ananya Anand, Vanshika Vanshika, Anujit Balo, Dr. Farhan Ahmed, Mirzada Mohd Qounane, Koyel Banerjee-Ghosh, Ritaban Halder, Shirsendu Ghosh
This paper develops a one-pot, physiologically compatible synthesis of papain-stabilized copper nanoclusters using NADH as a reducing agent, showing enhanced helical stability and effective drug delivery with reduced IC50 in cancer cells.
bioRxiv · Apr 23, 2026 · PreprintBioengineering