NeuroscienceNature CommunicationsPeer-reviewed
Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission
You-Kyung Lee, Cong Xiao, Xiaoting Zhou…·Zhenyu Yue
This study identifies AKAP11 as a critical autophagy receptor linking PKA kinase network regulation to synaptic transmission, with loss-of-function impacting pathways associated with bipolar disorder and schizophrenia.