Author

You-Kyung Lee

Icahn School of Medicine at Mount SinaiORCID 0000-0002-0818-0080Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Henry KimiD· 2 shared Junmin PengiD· 2 shared Nan YangiD· 2 shared Xian HaniD· 2 shared Xianting LiiD· 2 shared Xiaoting ZhouiD· 2 shared Zhenyu YueiD· 2 shared Beisha TangiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Henry KimORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission

You-Kyung Lee, Cong Xiao, Xiaoting Zhou, Leo L. Wang, Meghan G. McReynolds, Zhiping Wu, Xian Han, Eric Purisic, Henry Kim, Xianting Li, Zhiping P. Pang, Jinye Dai, Junmin Peng, Nan Yang, Zhenyu Yue

This study identifies AKAP11 as a critical autophagy receptor linking PKA kinase network regulation to synaptic transmission, with loss-of-function impacting pathways associated with bipolar disorder and schizophrenia.

Nature Communications · Nov 28, 2025Peer-reviewedNeuroscience

Integrated proteomics reveals the landscape of autophagy degradation in human neurons and autophagy receptors regulating neuronal activity

Xiaoting Zhou, You-Kyung Lee, Xianting Li, Henry Kim, Carlos Sánchez-Priego, Xian Han, Haiyan Tan, Suiping Zhou, Yingxue Fu, Kerry Purtell, Qian Wang, Gay R. Holstein, Beisha Tang, Junmin Peng, Nan Yang, Zhenyu Yue

The paper uses integrated proteomics to identify autophagy targets and receptors in human neurons, revealing their role in degradation and neuronal activity regulation.

bioRxiv · Dec 4, 2022 · PreprintNeuroscience