Nan Yang

This study identifies 38 expression-modulating variants associated with neurodevelopmental disorders and links them to neurodevelopmental transcriptional programs using MPRA and CROP-seq.

The paper introduces ME-seq, a technology that profiles DNA methylation, gene expression, and chromatin accessibility in single nuclei, revealing early microglial priming in Alzheimer's disease.

This study identifies AKAP11 as a critical autophagy receptor linking PKA kinase network regulation to synaptic transmission, with loss-of-function impacting pathways associated with bipolar disorder and schizophrenia.

This study investigates the neural mechanisms of cooperation in mice, showing that the medial prefrontal cortex encodes leadership dynamics and social value maps in an asymmetric, role-specific manner.

This study develops a method to generate diverse GABAergic neurons from PSCs using TFs and signaling inhibition, showing distinct subtype compositions and disease relevance.

The paper uses integrated proteomics to identify autophagy targets and receptors in human neurons, revealing their role in degradation and neuronal activity regulation.