Sanne M. Casello

This study investigates subcortico-thalamo-cortical circuits in mouse ventromedial thalamus, showing SNr inputs inhibit TC cells and route through VM to influence mPFC circuits.

The paper shows that vmPFC Dyn neurons suppress defensive behaviors by releasing dynorphin in response to threats and promoting fear-related network states.

This paper investigates how the dynorphin/kappa-opioid receptor system modulates excitation-inhibition balance in prefrontal cortical circuits through pathway-specific mechanisms.

This study shows that dynorphin release in the prefrontal cortex during opioid withdrawal disrupts cognition, and KOR antagonism can block these effects.