Lin Tian

The paper shows that localized dopamine from locus coeruleus axons selectively enhances specific hippocampal neurons during navigation, delaying action timing and improving reward anticipation.

The paper uses imaging and biochemical methods to analyze the effects of GCaMP overexpression on mammalian cells, identifying cellular morphology changes and cytoskeletal interactions.

This study shows that enkephalin released in the amygdala during fear learning suppresses dopamine release, thereby constraining fear memory formation.

This paper demonstrates that magnetic control of astrocytic calcium signaling can modulate neural circuit activity, introducing a tool for wireless, cell-specific calcium regulation.

The paper identifies a functional dichotomy in the ventrolateral periaqueductal gray, showing that micro opioid receptor neurons encode nociceptive states while enkephalin-releasing neurons drive pain relief in various contexts.

This study shows that vesicular glutamate release via VGluT1 is essential for neural tube formation in Xenopus laevis embryos, as its disruption leads to neural tube defects.

The paper develops a computational model of astrocytic calcium signaling that predicts refractory periods through a feedback mechanism involving cPKC, validated with in vivo imaging data.

The paper shows that hunger increases exploration by modulating dopamine signaling in the tail of the striatum via AgRP neurons.

The paper develops FLIPR, a system for absolute fluorescence lifetime measurement in mice, revealing spatial and temporal variations in dopamine signaling.

This study identifies meningeal regulatory T cells (mTregs) expressing enkephalin that modulate mechanical pain sensitivity in female mice via a sex hormone-dependent opioid receptor mechanism.

This study identifies the neural circuits underlying placebo analgesia, showing that cortical control of the descending pain modulatory system (DPMS) drives pain suppression through endogenous opioid signaling in the periaqueductal gray.

The paper shows how stochastic neuropeptide signals (NPY and MSH) compete to regulate cAMP levels in neurons, influencing satiation through state-dependent integration.

This study shows that dopamine release patterns in the dorsal striatum differ between medial and lateral regions during learning, challenging classic reinforcement learning models.

This study shows that dietary protein restriction reduces sucrose consumption and mesolimbic dopamine signaling in mice.

This study shows dynorphin modulates motivation via a pallido-amygdala cholinergic circuit by both disinhibiting and autoinhibiting cholinergic transmission in mice.

This study identifies the role of endogenous dynorphin release in the dorsal striatum in regulating goal-directed behavior through retrograde GPCR inhibition.

The paper shows that vmPFC Dyn neurons suppress defensive behaviors by releasing dynorphin in response to threats and promoting fear-related network states.

This paper introduces a micro-fiber array system for measuring and manipulating neural dynamics in large brain volumes during behavior, revealing spatiotemporal patterns of dopamine release and enabling precise optogenetic control.

This study shows that phasic locus coeruleus activity enhances trace fear conditioning by increasing hippocampal dopamine release, which is critical for memory formation.

The paper shows that pubertal androgen exposure programs adult behavioral responses to social defeat stress, with effects mediated by the bed nucleus of the stria terminalis.

The paper evaluates dLight photometry for measuring dopamine dynamics in the dorsolateral striatum, showing it can detect dopamine increases and transient kinetics during cocaine exposure and conditioning.

This study uses dopamine sensors and machine learning to analyze how dopamine dynamics in the dorsal and ventral striatum of mice correlate with behavioral patterns during exploratory behavior.

This study shows that dynorphin release in the prefrontal cortex during opioid withdrawal disrupts cognition, and KOR antagonism can block these effects.

This paper introduces a method to detect dopamine using genetically encoded fluorescent sensors in vitro and ex vivo, demonstrating its application for measuring dopamine release, uptake, and efflux.

This paper introduces parapinopsin (PPO), a photoswitchable GPCR-based opsin that enables rapid and reversible presynaptic inhibition, and demonstrates its utility in vivo.

This study shows that interrupting continuous opioid exposure increases drug-evoked adaptations in the mesolimbic dopamine system, leading to greater behavioral and transcriptional changes.

The paper shows that GRP recruits disinhibitory cortical circuits via VIP cells, enhancing fear memories through GRPR signaling.

The paper shows dopamine modulates PKA in striatal neurons during reward learning, with D1R and D2R neurons responding oppositely to dopamine changes.

SynQuant quantifies synapses from microscopy images by addressing antibody specificity, brightness heterogeneity, and noise, showing improved performance over existing tools in disease models.

This study shows heroin activates specific dopamine neurons in the ventral tegmental area projecting to the medial shell of the nucleus accumbens, and manipulations of these neurons affect heroin reinforcement.