Wolfgang Michael Kuebler

Myeloid cell recruitment propels right ventricular dysfunction in HFpEF via sterile inflammation.

This paper shows that myeloid cell recruitment drives right ventricular dysfunction in HFpEF through sterile inflammation in both mice and humans.

Overventilation-induced airspace acidification increases susceptibility to Pseudomonas pneumonia

This study shows that high tidal volume ventilation acidifies alveolar lining fluid, increasing susceptibility to Pseudomonas pneumonia by reducing NHE1 expression.

Lung microvascular rarefaction impairs pulmonary gas exchange and exacerbates heart failure with preserved ejection fraction

This study identifies pulmonary microvascular rarefaction as a novel mechanism in heart failure, linking it to impaired gas exchange and worsened cardiac function.

Horizon: CNV interpretation through rapid automated ACMG-aligned pathogenicity analysis

The paper evaluates the Horizon model, a CNV classification tool aligned with ACMG guidelines, showing high accuracy in pathogenicity prediction across multiple datasets.

LOSS OF ROR2 TYROSINE KINASE RECEPTOR IS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION IN PAH VIA INAPPROPRIATE INTEGRIN BETA 1 ACTIVATION

This study shows that loss of ROR2 leads to endothelial dysfunction in PAH through inappropriate integrin beta 1 activation, impairing barrier integrity and angiogenesis.

Neutrophil-chemoattractant CXCL5 induces lung barrier permeability in acute lung injury

This study identifies CXCL5 as a factor that increases alveolar-epithelial barrier permeability in acute lung injury, independent of neutrophil recruitment.

Gut microbial metabolite imidazole propionate impairs endothelial cell function and promotes the development of atherosclerosis

This study shows that gut microbial metabolite imidazole propionate impairs endothelial function and promotes atherosclerosis in both human and animal models.

Cell surface RNA expression modulates alveolar epithelial function

This study identifies glycoRNA as a novel component of the alveolar epithelial glycocalyx and shows its role in barrier regulation and viral infection.

Pneumonia induced rise in glucagon promotes endothelial damage and vascular thrombogenicity

This study shows that pneumonia increases glucagon levels, which damages endothelial cells and promotes blood clotting, leading to cardiovascular issues.

Insights into standards of care: dexamethasone and antibodies against COVID-19 in hamster models

The paper evaluates dexamethasone and anti-SARS-CoV-2 antibodies in hamster models, showing reduced viral burden with antibodies and anti-inflammatory effects with dexamethasone, with synergistic benefits when combined.