Author
Columbia UniversityORCID 0000-0002-0965-0478Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Katherine Elizabeth Segar, Madeline E. Sherlock, Jeffrey S. Kieft
The paper identifies and classifies 163 putative Type IV IRESs from diverse viruses, revealing structural variations that correlate with functional differences.
Madeline E. Sherlock, Katherine E. Segar, Jeffrey S. Kieft
The paper identifies a compact Type IV IRES in the 3' UTR of megrivirus E, confirms its structure, and shows it enables translation of a downstream open reading frame with reduced activity compared to the 5' UTR IRES.
Madeline E. Sherlock, Conner J. Langeberg, Katherine E. Segar, Jeffrey S. Kieft
The paper identifies and characterizes viral RNA structures that regulate translation reinitiation through ribosome interactions, revealing conserved features and dynamic conformations.