Jeffrey S. Kieft

Enterovirus RNase L inhibiting RNAs are highly conserved with limited phylogenetic distribution

The paper identifies conserved structural features of PV1 ciRNA that inhibit RNase L and shows limited phylogenetic distribution of functional ciRNAs within Enterovirus coxsackiepol.

An A-rich linker between dengue virus tandem xrRNAs facilitates functional coordination

This paper identifies an A-rich linker between tandem xrRNAs in DENV2 that stabilizes their structural coupling, influencing sfRNA patterns and viral fitness.

Distribution and structural diversity of Type IV internal ribosome entry sites

The paper identifies and classifies 163 putative Type IV IRESs from diverse viruses, revealing structural variations that correlate with functional differences.

Tick-borne flavivirus exoribonuclease-resistant RNAs contain a 'double loop' structure

The paper identifies and characterizes a novel 'double loop' structure in tick-borne flavivirus xrRNAs, revealing a conserved mechanism of exoribonuclease resistance.

A compact viral IRES translates a downstream open reading frame

The paper identifies a compact Type IV IRES in the 3' UTR of megrivirus E, confirms its structure, and shows it enables translation of a downstream open reading frame with reduced activity compared to the 5' UTR IRES.

A conserved class of viral RNA structures regulate translation reinitiation through dynamic ribosome interactions

The paper identifies and characterizes viral RNA structures that regulate translation reinitiation through ribosome interactions, revealing conserved features and dynamic conformations.

The Giardia lamblia ribosome structure reveals divergence in translation and quality control pathways

This study determines the structure of the Giardia lamblia 80S ribosome, revealing evolutionary divergence in translation and quality control mechanisms compared to other eukaryotes.

Pervasiveness of exoribonuclease-resistant RNAs in plant viruses suggests new roles for these conserved RNA structures

The paper identifies xrRNAs in diverse plant viruses, showing their presence in intergenic regions and association with coding subgenomic RNAs, suggesting broader roles beyond 3'UTR processing.