Systems BiologyMolecular OmicsPeer-reviewed
Metabolic response to Parkinson’s disease recapitulated by the haploinsufficient phenotype of diploid yeast cells hemizygous for the adrenodoxin reductase gene
Duygu Dikicioǧlu, James W. M. T. Coxon, Stephen G. Oliver
The paper shows that yeast lacking one copy of ARH1 exhibits metabolic and transcriptional changes similar to those in Parkinson’s disease, suggesting yeast as a model for studying disease mechanisms.
DOI 10.1039/c9mo00090a