Duygu Dikicioǧlu

The paper develops an in silico model of Parkinson's disease to explore causality links in molecular pathways during disease progression.

The paper shows that yeast lacking one copy of ARH1 exhibits metabolic and transcriptional changes similar to those in Parkinson’s disease, suggesting yeast as a model for studying disease mechanisms.

The paper develops a deterministic model to study toxin-binding and cell death kinetics in killer yeast strains, revealing differences in toxin action pathways.

The paper uses constraint-based modeling to estimate enzyme abundance levels in yeast iron metabolism and identifies a mutualistic relationship between yeast and Streptomyces coelicolor.

The paper analyzes transcriptional regulatory networks in yeast to identify novel features of gene regulation in protein transactions, finding that transcriptional regulation is underrepresented and controlled by few regulators.