Author

Jorik F. Bot

Leiden University Medical CenterORCID 0000-0002-0991-1201Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Darnell Kammeron· 1 shared Mengyuan LiiD· 1 shared Niels GeijseniD· 1 shared Peng ShangiD· 1 shared Zhihan ZhaoiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperMolecular Biology

Darnell Kammeron

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1 paper

Recent·Most cited

Molecular BiologyCommunications BiologyPeer-reviewedJan 19, 2026

Temporal dynamics of collateral RNA cleavage by LbuCas13a in human cells

Jorik F. Bot, Zhihan Zhao, Mengyuan Li…·Niels Geijsen

This study demonstrates that LbuCas13a induces rapid, global collateral RNA cleavage in human cells, leading to apoptosis and revealing cleavage preferences and temporal dynamics.

12 citationstop 1%

humanbulk RNA-seq

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