Author

Peng Shang

Leiden University Medical CenterORCID 0000-0002-8707-4146Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Peng Shang1 paper · Doheny Eye Institute

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Niels GeijseniD· 2 shared Darnell Kammeron· 1 shared Dennis T.M. van den Berg· 1 shared John van der OOSTiD· 1 shared Jorik F. BotiD· 1 shared Mengyuan LiiD· 1 shared Raymond H.J. StaalsiD· 1 shared Richard A. NotebaartiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

Niels GeijsenORCID

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2 papers

Recent·Most cited

Molecular BiologyCommunications BiologyPeer-reviewedJan 19, 2026

Temporal dynamics of collateral RNA cleavage by LbuCas13a in human cells

Jorik F. Bot, Zhihan Zhao, Mengyuan Li…·Niels Geijsen

This study demonstrates that LbuCas13a induces rapid, global collateral RNA cleavage in human cells, leading to apoptosis and revealing cleavage preferences and temporal dynamics.

12 citationstop 1%

humanbulk RNA-seq

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Molecular BiologyThe CRISPR JournalPeer-reviewedJul 20, 2022

Modulating CRISPR-Cas genome editing using guide-complementary DNA oligonucleotides

Thomas Swartjes, Peng Shang, Dennis T.M. van den Berg…·Richard A. Notebaart

This study shows DNA oligonucleotides can inhibit Cas9 activity in human cells and in vitro by targeting the guide RNA and requiring a PAM-loop for effective inhibition.

DOI 10.1089/crispr.2022.0011

humanCRISPR screen

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