Niels Geijsen

The paper examines DNA methylation patterns in adult skeletal muscle, finding that sex, not spatial location, drives methylation variation and sex-specific transcriptional programs.

This study demonstrates that LbuCas13a induces rapid, global collateral RNA cleavage in human cells, leading to apoptosis and revealing cleavage preferences and temporal dynamics.

This study shows DNA oligonucleotides can inhibit Cas9 activity in human cells and in vitro by targeting the guide RNA and requiring a PAM-loop for effective inhibition.

The paper investigates how DUX4 induces a sequence of transcriptional changes leading to apoptosis in somatic cells by activating a stem-cell-like network.

The paper performs a genome-wide CRISPR/Cas9 screen to identify modulators of DUX4 cytotoxicity in FSHD but finds no key effectors other than DUX4 itself.

The paper shows that embryonic signals convert trophoblast stem cells into polar-like cells that pattern the blastocyst axis in vitro.

The paper maps gene expression changes during meiotic prophase-I in mice spermatogenesis, identifying key transitions and gene regulation patterns.